No - all data entry is in real time - which means as soon as as someone adds a test result for example, the result is saved to your database and is available on any other machine immediately without painful and worrisome synchronisation.
Sadly we have no control over national internet coverage, but mobile phone companies and the telecommunications business are working hard to increase access to the network every day.
If you see the spinning disk below this indicates a loss of internet connection and your data will not be saved.